chronic wasting disease humans

Chronic Wasting Disease refers to the irregularities, spongy degeneration in brains. Chronic wasting disease is one of several conditions known as prion diseases. All are neurological in nature and some can affect humans. Although the zoonotic potential of CWD is considered low, identification of multiple CWD strains and the potential for agent evolution upon serial passage hinders a definitive conclusion. A prevalence of >90% was reported among mule deer in facilities where the disease has been endemic for >2 years (2,6,7,12). In vCJD, homogeneity of the genotype at codon 129 and the clinical and pathologic phenotype were attributed to the patients’ exposure to the same prion strain, the agent of BSE. However, in 2002, the disease was confirmed for the first time in several free-ranging deer harvested in western Colorado in an area surrounding a commercial enclosure, where entrapped mule deer tested positive for CWD. The mode of transmission among deer and elk is not fully understood; however, evidence supports lateral transmission through direct animal-to-animal contact or as a result of indirect exposure to the causative agent in the environment, including contaminated feed and water sources (12). When disease-associated prions contact normal prions, they cause them to refold into their own abnormal shape. Whether such aggressive management will succeed in eliminating free-ranging foci of CWD remains to be determined. What kind of disease is it? When your body weight drops then your body, Lack of Nervous Activity – In advanced stages, Lack of Vision – Vision loss is also quite common among humans. The patient did not hunt but may have eaten venison from Michigan once when he was 1–2 years old. Carcasses of depopulated animals are incinerated or buried in accordance with local regulations. These studies characterized the molecular similarities of the agents causing BSE and vCJD and determined the lesion profile and incubation period patterns of different panels of mice inoculated by the two agents. Chronic Wasting Disease. No cervids have been held in captivity close to the area where the New Mexico deer was found, and the origin of the disease in this deer remains unknown. Because the number of studies seeking evidence for CWD transmission to humans is limited, more epidemiologic and laboratory studies should be conducted to monitor the possibility of such transmissions. CWD was first identified as a fatal wasting syndrome of captive mule deer in the late 1960s in research facilities in Colorado and was recognized as a TSE in 1978 (6,7). However, prion protein gene analysis of a blood sample from one of the patient’s parents indicated a GSS P102L mutation. Message not sent. In addition, CWD-positive, free-ranging deer have been identified in Wyoming to the west over the Continental Divide from the known CWD-endemic zone (20). Chronic wasting disease (CWD), sometimes commonly referred to as zombie deer disease is a transmissible spongiform encephalopathy (TSE) affecting deer. Free-ranging deer from areas surrounding the enclosure also tested positive for the disease but at substantially lower rates. In some animals, ataxia and head tremors may occur. The case-patient’s illness began with a seizure and progressed to fatigue, poor concentration, and depression. The only CJD case-patient <30 years of age in Colorado had iatrogenic CJD linked to receipt of human growth hormone injections. Chronic wasting disease of captive mule deer: a spongiform encephalopathy. It causes the animal’s brain to deteriorate and turn into a … Despite the decades-long endemicity of CWD in Colorado and Wyoming, the incidence of CJD and the age distribution of CJD case-patients in these two states are similar to those seen in other parts of the United States. Chronic Wasting Disease which is also known as CWD, is a highly contagious disease. Available from: Centers for Disease Control and Prevention. If such transmissions were to occur, they would potentially increase the extent and frequency of human exposure to the CWD agent.

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